Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients

Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients

Children undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug inte...

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Main Authors: Melanie Dubois MD, Avika Dixit MBBS, MPH, MBI, Gabriella Lamb MD, MPH
Format: Article
Language:English
Published: SAGE Publishing 2021-01-01
Series:Global Pediatric Health
Online Access:https://doi.org/10.1177/2333794X20981548
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spelling doaj-055cf28028f94d0e8113499c9980d59b2021-01-15T23:35:12ZengSAGE PublishingGlobal Pediatric Health2333-794X2021-01-01810.1177/2333794X20981548Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell RecipientsMelanie Dubois MD0Avika Dixit MBBS, MPH, MBI1Gabriella Lamb MD, MPH2Harvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAChildren undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug interactions. There are limited data that address the unique challenges for the management of TB in the pediatric transplant population. This review presents the current understanding of the epidemiology, clinical presentation, diagnosis, management, and prevention for pediatric transplant recipients with TB infection and disease. Further studies are needed to improve diagnosis of TB and optimize treatment outcomes for these patients.https://doi.org/10.1177/2333794X20981548
collection DOAJ
language English
format Article
sources DOAJ
author Melanie Dubois MD
Avika Dixit MBBS, MPH, MBI
Gabriella Lamb MD, MPH
spellingShingle Melanie Dubois MD
Avika Dixit MBBS, MPH, MBI
Gabriella Lamb MD, MPH
Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
Global Pediatric Health
author_facet Melanie Dubois MD
Avika Dixit MBBS, MPH, MBI
Gabriella Lamb MD, MPH
author_sort Melanie Dubois MD
title Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
title_short Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
title_full Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
title_fullStr Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
title_full_unstemmed Tuberculosis in Pediatric Solid Organ and Hematopoietic Stem Cell Recipients
title_sort tuberculosis in pediatric solid organ and hematopoietic stem cell recipients
publisher SAGE Publishing
series Global Pediatric Health
issn 2333-794X
publishDate 2021-01-01
description Children undergoing solid organ and hematopoietic stem cell transplantation are at high risk of morbidity and mortality from tuberculosis (TB) disease in the post-transplant period. Treatment of TB infection and disease in the post-transplant setting is complicated by immunosuppression and drug interactions. There are limited data that address the unique challenges for the management of TB in the pediatric transplant population. This review presents the current understanding of the epidemiology, clinical presentation, diagnosis, management, and prevention for pediatric transplant recipients with TB infection and disease. Further studies are needed to improve diagnosis of TB and optimize treatment outcomes for these patients.
url https://doi.org/10.1177/2333794X20981548
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AT avikadixitmbbsmphmbi tuberculosisinpediatricsolidorganandhematopoieticstemcellrecipients
AT gabriellalambmdmph tuberculosisinpediatricsolidorganandhematopoieticstemcellrecipients
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