Polymorphisms Contributing to Calcium Status: A Systematic Review
This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in gen...
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doaj-05499787ad2d46068aa21b9fd76d398f2021-08-26T14:09:47ZengMDPI AGNutrients2072-66432021-07-01132488248810.3390/nu13082488Polymorphisms Contributing to Calcium Status: A Systematic ReviewKatharina da Silva Lopes0Sarah Krull Abe1Graduate School of Public Health, St. Luke’s International University, Tokyo 104-0045, JapanCenter for Public Health Sciences, National Cancer Center, Division of Prevention, Tokyo 104-0045, JapanThis systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (<i>CASR</i>) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (<i>VDR</i>) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the <i>CYP24A1</i> SNP or <i>CLDN14</i>. This study identified several <i>CASR</i>, <i>VDR</i> and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements.https://www.mdpi.com/2072-6643/13/8/2488calcium requirementscalcium homeostasisSNPspolymorphismgenetic factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katharina da Silva Lopes Sarah Krull Abe |
spellingShingle |
Katharina da Silva Lopes Sarah Krull Abe Polymorphisms Contributing to Calcium Status: A Systematic Review Nutrients calcium requirements calcium homeostasis SNPs polymorphism genetic factors |
author_facet |
Katharina da Silva Lopes Sarah Krull Abe |
author_sort |
Katharina da Silva Lopes |
title |
Polymorphisms Contributing to Calcium Status: A Systematic Review |
title_short |
Polymorphisms Contributing to Calcium Status: A Systematic Review |
title_full |
Polymorphisms Contributing to Calcium Status: A Systematic Review |
title_fullStr |
Polymorphisms Contributing to Calcium Status: A Systematic Review |
title_full_unstemmed |
Polymorphisms Contributing to Calcium Status: A Systematic Review |
title_sort |
polymorphisms contributing to calcium status: a systematic review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-07-01 |
description |
This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (<i>CASR</i>) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (<i>VDR</i>) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the <i>CYP24A1</i> SNP or <i>CLDN14</i>. This study identified several <i>CASR</i>, <i>VDR</i> and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements. |
topic |
calcium requirements calcium homeostasis SNPs polymorphism genetic factors |
url |
https://www.mdpi.com/2072-6643/13/8/2488 |
work_keys_str_mv |
AT katharinadasilvalopes polymorphismscontributingtocalciumstatusasystematicreview AT sarahkrullabe polymorphismscontributingtocalciumstatusasystematicreview |
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