Polymorphisms Contributing to Calcium Status: A Systematic Review

This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in gen...

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Main Authors: Katharina da Silva Lopes, Sarah Krull Abe
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/13/8/2488
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spelling doaj-05499787ad2d46068aa21b9fd76d398f2021-08-26T14:09:47ZengMDPI AGNutrients2072-66432021-07-01132488248810.3390/nu13082488Polymorphisms Contributing to Calcium Status: A Systematic ReviewKatharina da Silva Lopes0Sarah Krull Abe1Graduate School of Public Health, St. Luke’s International University, Tokyo 104-0045, JapanCenter for Public Health Sciences, National Cancer Center, Division of Prevention, Tokyo 104-0045, JapanThis systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (<i>CASR</i>) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (<i>VDR</i>) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the <i>CYP24A1</i> SNP or <i>CLDN14</i>. This study identified several <i>CASR</i>, <i>VDR</i> and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements.https://www.mdpi.com/2072-6643/13/8/2488calcium requirementscalcium homeostasisSNPspolymorphismgenetic factors
collection DOAJ
language English
format Article
sources DOAJ
author Katharina da Silva Lopes
Sarah Krull Abe
spellingShingle Katharina da Silva Lopes
Sarah Krull Abe
Polymorphisms Contributing to Calcium Status: A Systematic Review
Nutrients
calcium requirements
calcium homeostasis
SNPs
polymorphism
genetic factors
author_facet Katharina da Silva Lopes
Sarah Krull Abe
author_sort Katharina da Silva Lopes
title Polymorphisms Contributing to Calcium Status: A Systematic Review
title_short Polymorphisms Contributing to Calcium Status: A Systematic Review
title_full Polymorphisms Contributing to Calcium Status: A Systematic Review
title_fullStr Polymorphisms Contributing to Calcium Status: A Systematic Review
title_full_unstemmed Polymorphisms Contributing to Calcium Status: A Systematic Review
title_sort polymorphisms contributing to calcium status: a systematic review
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2021-07-01
description This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (<i>CASR</i>) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (<i>VDR</i>) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the <i>CYP24A1</i> SNP or <i>CLDN14</i>. This study identified several <i>CASR</i>, <i>VDR</i> and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements.
topic calcium requirements
calcium homeostasis
SNPs
polymorphism
genetic factors
url https://www.mdpi.com/2072-6643/13/8/2488
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AT sarahkrullabe polymorphismscontributingtocalciumstatusasystematicreview
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