Effect of liraglutide and metformin on constitution, metabolism and micro-inflammatory state in newly diagnosed type 2 diabetic mellitus patients with obesity

• Main Authors: Xiu-Ping Han, Tao Sun, Li-Li Wang, Yu-Mei He, Mei Zhang, Zhuan-Xia Li, Lin-Juan Li, Yong-Li Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-08-01
• Series: Journal of Hainan Medical University
• Subjects: Type 2 diabetic mellitus with obesity; Liraglutide; Metformin; Micro-inflammation
• Online Access: http://www.hnykdxxb.com/PDF/201616/10.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the effect of liraglutide and metformin on the constitution, metabolism and micro-inflammatory state in newly diagnosed type 2 diabetic mellitus patients with obesity. Methods: A total of 55 cases of newly diagnosed type 2 diabetic mellitus patients with obesity were included for study and divided into observation group (n=30) and control group (n=25) according to different treatment plans. Control group received metformin treatment alone, observation group received liraglutide and metformin treatment, and levels of glucolipid metabolism indicators, body mass index and fibrinolytic activity-related indicators, microinflammation-related signaling pathways, illness-related indicators, etc of two groups were detected after one course of treatment. Results: FPG, GHbA1c, TC, TG and LDL-C values in venous blood of observation group after treatment were lower than those of control group; waistline, hipline and waist-hip ratio of observation group decreased after treatment, TM value was lower than that of control group while t-PA value was higher than that of control group; TLR4-NF-毷B signaling pathway and DAG/PKC signaling pathway downstream TLR4, p-NF-毷B p65, DAG and PKC protein expression levels of observation group after treatment were significantly lower than those of control group; serum APN, Nesfatin-1 and ISI values of observation group after treatment were higher than those of control group while LP, Chemerin, RBP4 and FINS values were lower than those of control group. Conclusions: Combined therapy of liraglutide and metformin can significantly improve the constitution of newly diagnosed type 2 diabetic mellitus patients with obesity, optimize the general condition and be expected to improve treatment outcome.