New evidence for balancing selection at the HLA-G locus in South Amerindians

New evidence for balancing selection at the HLA-G locus in South Amerindians

HLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations...

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Bibliographic Details
Main Authors: Tiago Degani Veit, Juciana Cazarolli, Francisco Mauro Salzano, Marion Schiengold, José Artur Bogo Chies
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2012-01-01
Series:Genetics and Molecular Biology
Subjects:
HLA-G 14 bp INDEL
balancing selection
Amerindians
pathogen resistance
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600005

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