Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses

Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses

RAG1 protein is one of the key component of RAG complex regulating the V(D)J recombination. There are only few studies for RAG1 concerning evolutionary history, detailed sequence and mutational hotspots. Herein, we present out datasets used for the recent comprehensive study of RAG1 based on sequenc...

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Main Authors: Abhishek Kumar, Anita Bhandari, Sandeep J. Sarde, Sekhar Muppavarapu, Ravi Tandon
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340916303092
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spelling doaj-05315596cc2f4b0ba7c4cd1fae0f6fcc2020-11-24T21:53:31ZengElsevierData in Brief2352-34092016-09-0188792Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analysesAbhishek Kumar0Anita Bhandari1Sandeep J. Sarde2Sekhar Muppavarapu3Ravi Tandon4Department of Genetics & Molecular Biology in Botany, Institute of Botany, Christian-Albrechts-University at Kiel, Kiel, Germany; Division of Molecular Genetic Epidemiology German Cancer Research Center, Heidelberg, GermanyMolecular Physiology, Institute of Zoology, Christian-Albrechts-University at Kiel, Kiel, GermanyDepartment of Genetics & Molecular Biology in Botany, Institute of Botany, Christian-Albrechts-University at Kiel, Kiel, Germany; Agrigenomics, Christian-Albrechts-University at Kiel, Kiel, GermanyAgrigenomics, Christian-Albrechts-University at Kiel, Kiel, GermanySchool of Biotechnology, Jawaharlal Nehru University, New Delhi, IndiaRAG1 protein is one of the key component of RAG complex regulating the V(D)J recombination. There are only few studies for RAG1 concerning evolutionary history, detailed sequence and mutational hotspots. Herein, we present out datasets used for the recent comprehensive study of RAG1 based on sequence, phylogenetic and genetic variant analyses (Kumar et al., 2015) [1]. Protein sequence alignment helped in characterizing the conserved domains and regions of RAG1. It also aided in unraveling ancestral RAG1 in the sea urchin. Human genetic variant analyses revealed 751 mutational hotspots, located both in the coding and the non-coding regions. For further analysis and discussion, see (Kumar et al., 2015) [1].http://www.sciencedirect.com/science/article/pii/S2352340916303092
collection DOAJ
language English
format Article
sources DOAJ
author Abhishek Kumar
Anita Bhandari
Sandeep J. Sarde
Sekhar Muppavarapu
Ravi Tandon
spellingShingle Abhishek Kumar
Anita Bhandari
Sandeep J. Sarde
Sekhar Muppavarapu
Ravi Tandon
Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
Data in Brief
author_facet Abhishek Kumar
Anita Bhandari
Sandeep J. Sarde
Sekhar Muppavarapu
Ravi Tandon
author_sort Abhishek Kumar
title Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
title_short Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
title_full Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
title_fullStr Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
title_full_unstemmed Data on the evolutionary history of the V(D)J recombination-activating protein 1 – RAG1 coupled with sequence and variant analyses
title_sort data on the evolutionary history of the v(d)j recombination-activating protein 1 – rag1 coupled with sequence and variant analyses
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2016-09-01
description RAG1 protein is one of the key component of RAG complex regulating the V(D)J recombination. There are only few studies for RAG1 concerning evolutionary history, detailed sequence and mutational hotspots. Herein, we present out datasets used for the recent comprehensive study of RAG1 based on sequence, phylogenetic and genetic variant analyses (Kumar et al., 2015) [1]. Protein sequence alignment helped in characterizing the conserved domains and regions of RAG1. It also aided in unraveling ancestral RAG1 in the sea urchin. Human genetic variant analyses revealed 751 mutational hotspots, located both in the coding and the non-coding regions. For further analysis and discussion, see (Kumar et al., 2015) [1].
url http://www.sciencedirect.com/science/article/pii/S2352340916303092
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