Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells.

Metastasis is a major cause of mortality in cancer patients. Invadopodia are considered to be crucial structures that allow cancer cells to penetrate across the extracellular matrix (ECM) by using matrix metalloproteinases (MMPs). Previously, we isolated a highly invasive A431-III subline from paren...

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Main Authors: Yo-Chuen Lin, Pei-Hsun Tsai, Chun-Yu Lin, Chia-Hsiung Cheng, Tsung-Han Lin, Kevin P H Lee, Kai-Yun Huang, Shih-Hsun Chen, Jiuan-Jiuan Hwang, Chithan C Kandaswami, Ming-Ting Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3749203?pdf=render