Osteoclasts’ Ability to Generate Trenches Rather Than Pits Depends on High Levels of Active Cathepsin K and Efficient Clearance of Resorption Products

Osteoclasts’ Ability to Generate Trenches Rather Than Pits Depends on High Levels of Active Cathepsin K and Efficient Clearance of Resorption Products

Until recently, it was well-accepted that osteoclasts resorb bone according to the resorption cycle model. This model is based on the assumption that osteoclasts are immobile during bone erosion, allowing the actin ring to be firmly attached and thereby provide an effective seal encircling the resor...

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Bibliographic Details
Main Authors: Xenia G. Borggaard, Dinisha C. Pirapaharan, Jean-Marie Delaissé, Kent Søe
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
cathepsin K
osteoclast
bone resorption
pit
trench
lysosome
Online Access:https://www.mdpi.com/1422-0067/21/16/5924

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