The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This st...
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doaj-051e575095b64e02af7c928333c66f922020-11-25T02:22:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7120210.1371/journal.pone.0071202The common variant rs11646213 is associated with preeclampsia in Han Chinese women.Ji-peng WanHan ZhaoTao LiChang-zhong LiXie-tong WangZi-Jiang ChenBACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.http://europepmc.org/articles/PMC3747203?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji-peng Wan Han Zhao Tao Li Chang-zhong Li Xie-tong Wang Zi-Jiang Chen |
spellingShingle |
Ji-peng Wan Han Zhao Tao Li Chang-zhong Li Xie-tong Wang Zi-Jiang Chen The common variant rs11646213 is associated with preeclampsia in Han Chinese women. PLoS ONE |
author_facet |
Ji-peng Wan Han Zhao Tao Li Chang-zhong Li Xie-tong Wang Zi-Jiang Chen |
author_sort |
Ji-peng Wan |
title |
The common variant rs11646213 is associated with preeclampsia in Han Chinese women. |
title_short |
The common variant rs11646213 is associated with preeclampsia in Han Chinese women. |
title_full |
The common variant rs11646213 is associated with preeclampsia in Han Chinese women. |
title_fullStr |
The common variant rs11646213 is associated with preeclampsia in Han Chinese women. |
title_full_unstemmed |
The common variant rs11646213 is associated with preeclampsia in Han Chinese women. |
title_sort |
common variant rs11646213 is associated with preeclampsia in han chinese women. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women. |
url |
http://europepmc.org/articles/PMC3747203?pdf=render |
work_keys_str_mv |
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