The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This st...

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Main Authors: Ji-peng Wan, Han Zhao, Tao Li, Chang-zhong Li, Xie-tong Wang, Zi-Jiang Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747203?pdf=render
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spelling doaj-051e575095b64e02af7c928333c66f922020-11-25T02:22:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7120210.1371/journal.pone.0071202The common variant rs11646213 is associated with preeclampsia in Han Chinese women.Ji-peng WanHan ZhaoTao LiChang-zhong LiXie-tong WangZi-Jiang ChenBACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.http://europepmc.org/articles/PMC3747203?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Ji-peng Wan
Han Zhao
Tao Li
Chang-zhong Li
Xie-tong Wang
Zi-Jiang Chen
spellingShingle Ji-peng Wan
Han Zhao
Tao Li
Chang-zhong Li
Xie-tong Wang
Zi-Jiang Chen
The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
PLoS ONE
author_facet Ji-peng Wan
Han Zhao
Tao Li
Chang-zhong Li
Xie-tong Wang
Zi-Jiang Chen
author_sort Ji-peng Wan
title The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
title_short The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
title_full The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
title_fullStr The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
title_full_unstemmed The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
title_sort common variant rs11646213 is associated with preeclampsia in han chinese women.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.
url http://europepmc.org/articles/PMC3747203?pdf=render
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