NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation

NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 provides an IEC-intrinsic protection against colitis-associated carc...

Full description

Bibliographic Details
Main Authors:	Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin
Format:	Article
Language:	English
Published:	Elsevier 2016-03-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124716301875

Similar Items

The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole
by: Ivan Tattoli, et al.
Published: (2012-10-01)

Modeling-Enabled Characterization of Novel NLRX1 Ligands.
by: Pinyi Lu, et al.
Published: (2015-01-01)

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
by: A. Alicia Koblansky, et al.
Published: (2016-03-01)

Stalling autophagy: a new function for Listeria phospholipases
by: Ivan Tattoli, et al.
Published: (2014-01-01)

NLRX1 Regulation Following Acute Mitochondrial Injury
by: Xiaogang Chu, et al.
Published: (2019-10-01)

NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function
by: Margaret A. Nagai-Singer, et al.
Published: (2019-10-01)

NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart
by: Hong Zhang, et al.
Published: (2020-12-01)

Focusing on the Cell Type Specific Regulatory Actions of NLRX1
by: Tünde Fekete, et al.
Published: (2021-01-01)

The role of NLRX1 and NLRP3 in Candida albicans infection
by: Chia Hsien Chuang, et al.
Published: (2017)

Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection.
by: Casandra W Philipson, et al.
Published: (2015-01-01)

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes
by: Shaimaa Mahmoud, et al.
Published: (2019-04-01)

The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition
by: Paul Lemire, et al.
Published: (2017-12-01)

NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin.
by: Angelique M L Scantlebery, et al.
Published: (2019-01-01)

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.
by: Marjan Gharagozloo, et al.
Published: (2019-09-01)

NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
by: Bridget Kastelberg, et al.
Published: (2020-09-01)

T cell intrinsic NOD2 is dispensable for CD8 T cell immunity.
by: Gloria H Y Lin, et al.
Published: (2013-01-01)

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages
by: Juin-Hua Huang, et al.
Published: (2018-12-01)

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency.
by: Zhe Ma, et al.
Published: (2017-05-01)

Emerging concepts in intestinal immune control of obesity-related metabolic disease
by: Saad Khan, et al.
Published: (2021-05-01)

NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host–Gut Microbiota Interactions during Inflammatory Bowel Disease
by: Andrew Leber, et al.
Published: (2018-02-01)

NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1–UVRAG Complex
by: Chihiro Aikawa, et al.
Published: (2018-11-01)

DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke
by: Li Peng, et al.
Published: (2020-03-01)

Le rôle du récepteur NOD-like, Nlrx1 dans la neuroprotection et la mort cellulaire
by: Imbeault, Emilie
Published: (2015)

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.
by: Jae-Hoon Kim, et al.
Published: (2017-05-01)

Cellular aspects of Shigella pathogenesis: Focus on the manipulation of host cell processes
by: Samuel A Killackey, et al.
Published: (2016-03-01)

Intrinsic Restriction of TNF-Mediated Inflammatory Osteoclastogenesis and Bone Resorption
by: Baohong Zhao, et al.
Published: (2020-10-01)

Correction: FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.
by: Jae-Hoon Kim, et al.
Published: (2018-09-01)

DNA Sequence and Haplotype Variation Analysis of Inflammatory Response Genes NLRX1, IL6, and IL8 in the Turkey (Meleagris gallopavo)
by: Russell, Kadijah Lashunte
Published: (2020)

Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma.
by: Yang Liu, et al.
Published: (2013-01-01)

Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
by: Aljahdali, Bushra Hameed
Published: (2019)

Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins
by: Hila Winer, et al.
Published: (2018-09-01)

An Update in Guillain-Barré Syndrome
by: J. B. Winer
Published: (2014-01-01)

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging
by: Saad Khan, et al.
Published: (2020-05-01)

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil.
by: Alain Ibáñez de Opakua, et al.
Published: (2017-01-01)

The Pain of the Wound and the Balm of having understood the Gods
by: Winer, Andrew
Published: (2018-12-01)

Indic Lexicon in the English/Creole of Trinidad
by: Lise Winer
Published: (2008-12-01)

Determining the Constitutionality of the National Securities Regulator Proposal and Beyond: The Federal Trade and Commerce Power, the General Motors test and the Choice Between ‘Categorization’ and ‘Balancing’
by: Winer, Oren S.
Published: (2011)

Determining the Constitutionality of the National Securities Regulator Proposal and Beyond: The Federal Trade and Commerce Power, the General Motors test and the Choice Between ‘Categorization’ and ‘Balancing’
by: Winer, Oren S.
Published: (2011)

A survey of perceptions of "normal" sexual functioning, behaviour, and preferences
by: Winer, Vicky
Published: (1981)

Las políticas de seguridad y defensa en Paraguay: Perspectivas y desafíos frente al nuevo escenario politico
by: Sonia Winer
Published: (2009-04-01)