Increased iNKT17 Cell Frequency in the Intestine of Non-Obese Diabetic Mice Correlates With High Bacterioidales and Low Clostridiales Abundance

Increased iNKT17 Cell Frequency in the Intestine of Non-Obese Diabetic Mice Correlates With High Bacterioidales and Low Clostridiales Abundance

iNKT cells play different immune function depending on their cytokine-secretion phenotype. iNKT17 cells predominantly secrete IL-17 and have an effector and pathogenic role in the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). In line with this notion, non-obese diabetic (NOD) mi...

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Bibliographic Details
Main Authors: Lorena De Giorgi, Chiara Sorini, Ilaria Cosorich, Roberto Ferrarese, Filippo Canducci, Marika Falcone
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
natural killer T cells
interleukin-17
dendritic cells
microbiota
autoimmune diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01752/full

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