HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses

HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses

The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is a potent immunomodulatory molecule at the maternal/fetal interface and other environments to regulate the cellular immune response. We created GGTA1-/HLAG1+ pigs to explore their use...

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Bibliographic Details
Main Authors: Joseph Sushil Rao, Nora Hosny, Ramesh Kumbha, Raza Ali Naqvi, Amar Singh, Zachary Swanson, Heather Levy, Anders W. Matson, Magie Steinhoff, Nicole Forneris, Eric Walters, Bernhard J. Hering, Christopher Burlak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
HLAG-1
CRIPSR/Cas9
porcine
islet
xenotransplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.730545/full

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