Role of Catecholamine in Tumor Angiogenesis Linked to Capacitance Relaxation Phenomenon

• Main Authors: Guangyue SHI, Guanjie SUI, Jianxia JIANG, T. K. BASAK
• Format: Article
• Language: English
• Published: IFSA Publishing, S.L. 2010-08-01
• Series: Sensors & Transducers
• Subjects: CgA level; Capacitance relaxation phenomenon; Tumor angiogenesis
• Online Access: http://www.sensorsportal.com/HTML/DIGEST/august_2010/P_673.pdf

The present paper deals with the CgA level during metastasis linked with Capacitance relaxation phenomenon in cancer cell. CgA co-stored and correlated by exocytosis with catecholamines is a precursor to peptides that exert feedback regulatory control on catecholamine secretion. It is to be noted that CgA was the most sensitive marker for detecting patients with tumor angiogenesis. The progressive rise in CgA increases with the tumor size and this fact has been correlated with the Capacitance relaxation phenomenon (T. K. Basak, US patent No. 5691178, 1997) in different stages. The experimental results of Capacitance relaxation phenomenon were given as inputs to a model for correlation with the CgA level. This model is a control system model, the output of which is the CgA level. It is to be noted that the model is simulated in MATLAB. The expression of tumorogenisis in prostate and liver is also linked to Capacitance relaxation phenomenon in respect of its correlation with the CgA level.