Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

<p>Abstract</p> <p>Background</p> <p>Parkinson's disease, the most common adult neurodegenerative movement disorder, demonstrates a brain-wide pathology that begins pre-clinically with alpha-synuclein aggregates ("Lewy neurites") in processes of gut enter...

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Bibliographic Details
Main Authors: Liu Lei, Mohanakumar KP, Keeney Paula M, Rubinstein Jeremy D, Trimmer Patricia A, Borland M Kathleen, Bennett James P
Format: Article
Language:English
Published: BMC 2008-12-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/3/1/21

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http://www.molecularneurodegeneration.com/content/3/1/21

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