LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling

LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling

Persistent T cell antigen receptor (TCR) signaling by CD8 T cells is a feature of cancer and chronic infections and results in the sustained expression of, and signaling by, inhibitory receptors, which ultimately impair cytotoxic activity via poorly characterized mechanisms. We have previously deter...

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Bibliographic Details
Main Authors: Divij Mathew, Kimberly N. Kremer, Pamela Strauch, Gabor Tigyi, Roberta Pelanda, Raul M. Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
CD8 T cells
lysophosphatidic acid
TCR signaling
granule exocytosis
cytotoxicity
inhibitory receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01159/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01159/full

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