Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.

Neisseria meningitidis is a human exclusive pathogen that can lead to invasive meningococcal disease or may be carried in the upper respiratory tract without symptoms. The relationship between carriage and disease remains poorly understood but it is widely accepted that decreasing carriage by immuni...

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Main Authors: Paulina S Rubilar, Gisselle N Barra, Jean-Marc Gabastou, Pedro Alarcón, Pamela Araya, Juan C Hormazábal, Jorge Fernandez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5843251?pdf=render
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spelling doaj-04db6294863343a6acdfdaea58ce18492020-11-25T02:47:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01133e019357210.1371/journal.pone.0193572Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.Paulina S RubilarGisselle N BarraJean-Marc GabastouPedro AlarcónPamela ArayaJuan C HormazábalJorge FernandezNeisseria meningitidis is a human exclusive pathogen that can lead to invasive meningococcal disease or may be carried in the upper respiratory tract without symptoms. The relationship between carriage and disease remains poorly understood but it is widely accepted that decreasing carriage by immunization should lead to a reduction of invasive cases. Latin America has experienced an increased incidence of serogroup W invasive cases of Neisseria meningitidis in the last decade. Specifically in Chile, despite low total incidence of invasive cases, serogroup W has become predominant since 2011 and has been associated with elevated mortality. Expecting to gain insight into the epidemiology of this disease, this study has used molecular typing schemes to compare Neisseria meningitidis isolates causing invasive disease with those isolates collected from adolescent carriers during the same period in Chile. A lower carriage of the serogroup W clonal complex ST-11/ET37 than expected was found; whereas, the same clonal complex accounted for 66% of total invasive meningococcal disease cases in the country that year. A high diversity of PorA variable regions and fHbp peptides was also ascertained in the carrier isolates compared to the invasive ones. According to the results shown here, the elevated number of serogroup W invasive cases in our country cannot be explained by a rise of carriage of pathogenic isolates. Overall, this study supports the idea that some strains, as W:cc11 found in Chile, possess an enhanced virulence to invade the host. Notwithstanding hypervirulence, this strain has not caused an epidemic in Chile. Finally, as genetic transfer occurs often, close surveillance of Neisseria meningitidis strains causing disease, and particularly hypervirulent W:cc11, should be kept as a priority in our country, in order to prepare the best response to face genetic changes that could lead to enhanced fitness of this pathogen.http://europepmc.org/articles/PMC5843251?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Paulina S Rubilar
Gisselle N Barra
Jean-Marc Gabastou
Pedro Alarcón
Pamela Araya
Juan C Hormazábal
Jorge Fernandez
spellingShingle Paulina S Rubilar
Gisselle N Barra
Jean-Marc Gabastou
Pedro Alarcón
Pamela Araya
Juan C Hormazábal
Jorge Fernandez
Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
PLoS ONE
author_facet Paulina S Rubilar
Gisselle N Barra
Jean-Marc Gabastou
Pedro Alarcón
Pamela Araya
Juan C Hormazábal
Jorge Fernandez
author_sort Paulina S Rubilar
title Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
title_short Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
title_full Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
title_fullStr Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
title_full_unstemmed Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.
title_sort increase of neisseria meningitidis w:cc11 invasive disease in chile has no correlation with carriage in adolescents.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description Neisseria meningitidis is a human exclusive pathogen that can lead to invasive meningococcal disease or may be carried in the upper respiratory tract without symptoms. The relationship between carriage and disease remains poorly understood but it is widely accepted that decreasing carriage by immunization should lead to a reduction of invasive cases. Latin America has experienced an increased incidence of serogroup W invasive cases of Neisseria meningitidis in the last decade. Specifically in Chile, despite low total incidence of invasive cases, serogroup W has become predominant since 2011 and has been associated with elevated mortality. Expecting to gain insight into the epidemiology of this disease, this study has used molecular typing schemes to compare Neisseria meningitidis isolates causing invasive disease with those isolates collected from adolescent carriers during the same period in Chile. A lower carriage of the serogroup W clonal complex ST-11/ET37 than expected was found; whereas, the same clonal complex accounted for 66% of total invasive meningococcal disease cases in the country that year. A high diversity of PorA variable regions and fHbp peptides was also ascertained in the carrier isolates compared to the invasive ones. According to the results shown here, the elevated number of serogroup W invasive cases in our country cannot be explained by a rise of carriage of pathogenic isolates. Overall, this study supports the idea that some strains, as W:cc11 found in Chile, possess an enhanced virulence to invade the host. Notwithstanding hypervirulence, this strain has not caused an epidemic in Chile. Finally, as genetic transfer occurs often, close surveillance of Neisseria meningitidis strains causing disease, and particularly hypervirulent W:cc11, should be kept as a priority in our country, in order to prepare the best response to face genetic changes that could lead to enhanced fitness of this pathogen.
url http://europepmc.org/articles/PMC5843251?pdf=render
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