Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons

Synaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional characterization of unitary synaptic transmission at the ce...

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Main Authors: Guanxiao Qi, Danqing Yang, Chao Ding, Dirk Feldmeyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2020.00005/full
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spelling doaj-04d794e279d84105a84438815e352df32020-11-25T01:16:33ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632020-02-011210.3389/fnsyn.2020.00005495625Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled NeuronsGuanxiao Qi0Danqing Yang1Chao Ding2Dirk Feldmeyer3Dirk Feldmeyer4Dirk Feldmeyer5Institute of Neuroscience and Medicine, INM-10, Jülich Research Centre, Jülich, GermanyInstitute of Neuroscience and Medicine, INM-10, Jülich Research Centre, Jülich, GermanyInstitute of Neuroscience and Medicine, INM-10, Jülich Research Centre, Jülich, GermanyInstitute of Neuroscience and Medicine, INM-10, Jülich Research Centre, Jülich, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University Hospital, Aachen, GermanyJülich-Aachen Research Alliance, Translational Brain Medicine (JARA Brain), Aachen, GermanySynaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional characterization of unitary synaptic transmission at the cellular and synaptic level in combination with a structural characterization of both pre- and postsynaptic neurons at the light and electron microscopic level. In this review, we will summarize the many applications of paired recordings to investigate synaptic function and structure. Paired recordings have been used to study the detailed electrophysiological and anatomical properties of synaptically coupled cell pairs within a synaptic microcircuit; this is critical in order to understand the connectivity rules and dynamic properties of synaptic transmission. Paired recordings can also be adopted for quantal analysis of an identified synaptic connection and to study the regulation of synaptic transmission by neuromodulators such as acetylcholine, the monoamines, neuropeptides, and adenosine etc. Taken together, paired recordings from synaptically coupled neurons will remain a very useful approach for a detailed characterization of synaptic transmission not only in the rodent brain but also that of other species including humans.https://www.frontiersin.org/article/10.3389/fnsyn.2020.00005/fullpaired recordingssynaptic connectionstructure-function analysisquantal analysisneuromodulation
collection DOAJ
language English
format Article
sources DOAJ
author Guanxiao Qi
Danqing Yang
Chao Ding
Dirk Feldmeyer
Dirk Feldmeyer
Dirk Feldmeyer
spellingShingle Guanxiao Qi
Danqing Yang
Chao Ding
Dirk Feldmeyer
Dirk Feldmeyer
Dirk Feldmeyer
Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
Frontiers in Synaptic Neuroscience
paired recordings
synaptic connection
structure-function analysis
quantal analysis
neuromodulation
author_facet Guanxiao Qi
Danqing Yang
Chao Ding
Dirk Feldmeyer
Dirk Feldmeyer
Dirk Feldmeyer
author_sort Guanxiao Qi
title Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
title_short Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
title_full Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
title_fullStr Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
title_full_unstemmed Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
title_sort unveiling the synaptic function and structure using paired recordings from synaptically coupled neurons
publisher Frontiers Media S.A.
series Frontiers in Synaptic Neuroscience
issn 1663-3563
publishDate 2020-02-01
description Synaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional characterization of unitary synaptic transmission at the cellular and synaptic level in combination with a structural characterization of both pre- and postsynaptic neurons at the light and electron microscopic level. In this review, we will summarize the many applications of paired recordings to investigate synaptic function and structure. Paired recordings have been used to study the detailed electrophysiological and anatomical properties of synaptically coupled cell pairs within a synaptic microcircuit; this is critical in order to understand the connectivity rules and dynamic properties of synaptic transmission. Paired recordings can also be adopted for quantal analysis of an identified synaptic connection and to study the regulation of synaptic transmission by neuromodulators such as acetylcholine, the monoamines, neuropeptides, and adenosine etc. Taken together, paired recordings from synaptically coupled neurons will remain a very useful approach for a detailed characterization of synaptic transmission not only in the rodent brain but also that of other species including humans.
topic paired recordings
synaptic connection
structure-function analysis
quantal analysis
neuromodulation
url https://www.frontiersin.org/article/10.3389/fnsyn.2020.00005/full
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