Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

Abstract Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representat...

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Bibliographic Details
Main Authors: Lars R. Ingerslev, Ida Donkin, Odile Fabre, Soetkin Versteyhe, Mie Mechta, Pattarawan Pattamaprapanont, Brynjulf Mortensen, Nikolaj Thure Krarup, Romain Barrès
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Clinical Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13148-018-0446-7

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