Naphthalimides Induce G2 Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells

Naphthalimides Induce G2 Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells

Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G2-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. The current study was designed to pre...

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Bibliographic Details
Main Authors:	Hong Zhu, Ze-Hong Miao, Min Huang, Jian-Ming Feng, Zhi-Xiang Zhang, Jin-Jian Lu, Yu-Jun Cai, Lin-Jiang Tong, Yu-Fang Xu, Xu-Hong Qian, Jian Ding
Format:	Article
Language:	English
Published:	Elsevier 2009-11-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558609800808

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