Combination Treatment With Metformin and Tacrolimus Improves Systemic Immune Cellular Homeostasis by Modulating Treg and Th17 Imbalance

Combination Treatment With Metformin and Tacrolimus Improves Systemic Immune Cellular Homeostasis by Modulating Treg and Th17 Imbalance

We examined the effect of combination therapy with metformin and tacrolimus on immune parameters including T regulatory (Treg) and type 17 helper T (Th17) cells in vitro and in vivo in mice and in liver transplantation (LT) patients. T cell proliferation and subtypes after in vitro T cell activation...

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Bibliographic Details
Main Authors: Soon Kyu Lee, Min-Jung Park, Joo Yeon Jhun, Jin-Ah Beak, Jeong Won Choi, Jae-Yoon Rye, Jeong Won Jang, Si Hyun Bae, Seung Kew Yoon, Ho Joong Choi, Young Kyoung You, Mi-La Cho, Jong Young Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
metformin
tacrolimus
regulatory T cell
Th17 cell
allogeneic response
GVHD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.581728/full

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