Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress

Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress

Abstract CHK1 is a crucial DNA damage checkpoint kinase and its activation, which requires ATR and RAD17, leads to inhibition of DNA replication and cell cycle progression. Recently, we reported that SMG7 stabilizes and activates p53 to induce G1 arrest upon DNA damage; here we show that SMG7 plays...

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Bibliographic Details
Main Authors: Kathleen Ho, Hongwei Luo, Wei Zhu, Yi Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86957-x

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