Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease

Background. VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. Aim. To assess the association between serum VCAM-1 (sVCAM-1) levels and features of tumour...

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Main Authors: Antonio Diaz-Sanchez, Ana Matilla, Oscar Nuñez, Diego Rincon, Raquel Lorente, Oreste Lo lacono, Beatriz Merino, Ana Hernando, Rocio Campos, Gerardo Clemente, Rafael Bañares
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Annals of Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119313626
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spelling doaj-04be7633f367418d98564de37e7c8d432021-06-09T05:54:19ZengElsevierAnnals of Hepatology1665-26812013-03-01122236247Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver diseaseAntonio Diaz-Sanchez0Ana Matilla1Oscar Nuñez2Diego Rincon3Raquel Lorente4Oreste Lo lacono5Beatriz Merino6Ana Hernando7Rocio Campos8Gerardo Clemente9Rafael Bañares10Gastroenterology Unit, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Correspondence and reprint request:Liver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainGastroenterology Unit, Hospital Universitario Infanta Sofia, San Sebastian de los Reyes, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainGastroenterology Unit, Hospital del Tajo. Aranjuez, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainGastroenterology Unit, Hospital Universitario del Sureste, Arganda del Rey, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainLiver Unit-CIBEREHD, Hospital General Universitario Gregorio Marañon, Madrid, SpainBackground. VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. Aim. To assess the association between serum VCAM-1 (sVCAM-1) levels and features of tumour and liver disease in patients with and without HCC, and to study the influence of HCC treatment on sVCAM-1 levels.Material and methods. Concentrations in peripheral (sVCAM-1-P) and hepatic (sVCAM-1-H) veins were analysed using ELISA in 134 consecutive patients with chronic liver disease between May 2004 and February 2006, who underwent a splanchnic haemodynamic study. Of these patients, 58 had HCC.Results. sVCAM-1-P and sVCAM-1-H were well correlated in both groups. No association was found between sVCAM-1-H and tumour features. No differences were observed in sVCAM-1-H between HCC and non-HCC cirrhotic patients. There was a significant linear association between Child-Pugh stage and sVCAM-1-H in HCC-patients (Child-Pugh A [2,485 ± 1,294 ng/mL] vs. Child-Pugh B [3,408 ± 1,338 ng/mL] vs. Child-Pugh C [4,096 ± 862 ng/ mL]; p = 0.007). Seven non-cirrhotic HCC patients had a significantly lower sVCAM-1-H than cirrhotic HCC patients. Treatment of HCC leads to an increase in sVCAM-1-H levels although this was not associated with the necrosis response to treatment.Conclusions. sVCAM-1 levels are more closely associated with the severity of underlying liver disease than with the presence of HCC. sVCAM-1 levels are not associated with tumour features or invasiveness; therefore, sVCAM-1 does not seem to play an important role in the angiogenic processes of HCC.http://www.sciencedirect.com/science/article/pii/S1665268119313626CirrhosisHyaluronic AcidVascular cell adhesion molecule-1
collection DOAJ
language English
format Article
sources DOAJ
author Antonio Diaz-Sanchez
Ana Matilla
Oscar Nuñez
Diego Rincon
Raquel Lorente
Oreste Lo lacono
Beatriz Merino
Ana Hernando
Rocio Campos
Gerardo Clemente
Rafael Bañares
spellingShingle Antonio Diaz-Sanchez
Ana Matilla
Oscar Nuñez
Diego Rincon
Raquel Lorente
Oreste Lo lacono
Beatriz Merino
Ana Hernando
Rocio Campos
Gerardo Clemente
Rafael Bañares
Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
Annals of Hepatology
Cirrhosis
Hyaluronic Acid
Vascular cell adhesion molecule-1
author_facet Antonio Diaz-Sanchez
Ana Matilla
Oscar Nuñez
Diego Rincon
Raquel Lorente
Oreste Lo lacono
Beatriz Merino
Ana Hernando
Rocio Campos
Gerardo Clemente
Rafael Bañares
author_sort Antonio Diaz-Sanchez
title Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
title_short Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
title_full Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
title_fullStr Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
title_full_unstemmed Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
title_sort serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
publisher Elsevier
series Annals of Hepatology
issn 1665-2681
publishDate 2013-03-01
description Background. VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. Aim. To assess the association between serum VCAM-1 (sVCAM-1) levels and features of tumour and liver disease in patients with and without HCC, and to study the influence of HCC treatment on sVCAM-1 levels.Material and methods. Concentrations in peripheral (sVCAM-1-P) and hepatic (sVCAM-1-H) veins were analysed using ELISA in 134 consecutive patients with chronic liver disease between May 2004 and February 2006, who underwent a splanchnic haemodynamic study. Of these patients, 58 had HCC.Results. sVCAM-1-P and sVCAM-1-H were well correlated in both groups. No association was found between sVCAM-1-H and tumour features. No differences were observed in sVCAM-1-H between HCC and non-HCC cirrhotic patients. There was a significant linear association between Child-Pugh stage and sVCAM-1-H in HCC-patients (Child-Pugh A [2,485 ± 1,294 ng/mL] vs. Child-Pugh B [3,408 ± 1,338 ng/mL] vs. Child-Pugh C [4,096 ± 862 ng/ mL]; p = 0.007). Seven non-cirrhotic HCC patients had a significantly lower sVCAM-1-H than cirrhotic HCC patients. Treatment of HCC leads to an increase in sVCAM-1-H levels although this was not associated with the necrosis response to treatment.Conclusions. sVCAM-1 levels are more closely associated with the severity of underlying liver disease than with the presence of HCC. sVCAM-1 levels are not associated with tumour features or invasiveness; therefore, sVCAM-1 does not seem to play an important role in the angiogenic processes of HCC.
topic Cirrhosis
Hyaluronic Acid
Vascular cell adhesion molecule-1
url http://www.sciencedirect.com/science/article/pii/S1665268119313626
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