The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity
Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also p...
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00048/full |
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doaj-04bd3d030ef84ff5aed082382d8784252020-11-24T23:47:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2015-08-01310.3389/fcell.2015.00048152962The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticityStephanie eWallner0Sebastian ePeters1Claudia ePitzer2Herbert eResch3Herbert eResch4Ulrich eBogdahn5Armin eSchneider6Paracelsus Medical University SalzburgUniversity Hospital RegensburgRuprecht-Karls-UniversityParacelsus Medical University SalzburgParacelsus Medical University SalzburgUniversity Hospital RegensburgSYGNIS Bioscience GmbHGranulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00048/fullNeurogenesisplasticityAngiogenesisALSscigrowth factor |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stephanie eWallner Sebastian ePeters Claudia ePitzer Herbert eResch Herbert eResch Ulrich eBogdahn Armin eSchneider |
| spellingShingle |
Stephanie eWallner Sebastian ePeters Claudia ePitzer Herbert eResch Herbert eResch Ulrich eBogdahn Armin eSchneider The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity Frontiers in Cell and Developmental Biology Neurogenesis plasticity Angiogenesis ALS sci growth factor |
| author_facet |
Stephanie eWallner Sebastian ePeters Claudia ePitzer Herbert eResch Herbert eResch Ulrich eBogdahn Armin eSchneider |
| author_sort |
Stephanie eWallner |
| title |
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| title_short |
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| title_full |
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| title_fullStr |
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| title_full_unstemmed |
The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| title_sort |
granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cell and Developmental Biology |
| issn |
2296-634X |
| publishDate |
2015-08-01 |
| description |
Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor. |
| topic |
Neurogenesis plasticity Angiogenesis ALS sci growth factor |
| url |
http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00048/full |
| work_keys_str_mv |
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