The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also p...

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Bibliographic Details
Main Authors: Stephanie eWallner, Sebastian ePeters, Claudia ePitzer, Herbert eResch, Ulrich eBogdahn, Armin eSchneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Neurogenesis
plasticity
Angiogenesis
ALS
sci
growth factor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00048/full
Description
Summary:Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.
ISSN:2296-634X

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