Multiple Origins and Specific Evolution of CRISPR/Cas9 Systems in Minimal Bacteria (Mollicutes)

Multiple Origins and Specific Evolution of CRISPR/Cas9 Systems in Minimal Bacteria (Mollicutes)

CRISPR/Cas systems provide adaptive defense mechanisms against invading nucleic acids in prokaryotes. Because of its interest as a genetic tool, the Type II CRISPR/Cas9 system from Streptococcus pyogenes has been extensively studied. It includes the Cas9 endonuclease that is dependent on a dual-guid...

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Bibliographic Details
Main Authors: Thomas Ipoutcha, Iason Tsarmpopoulos, Vincent Talenton, Christine Gaspin, Annick Moisan, Caray A. Walker, Joe Brownlie, Alain Blanchard, Patricia Thebault, Pascal Sirand-Pugnet
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
CRISPR/Cas9
mollicutes
mycoplasma
spiroplasma
phage
mobile genetic elements
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02701/full

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