Cell barrier function of resident peritoneal macrophages in post-operative adhesions

Peritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80HighCD206− macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of thes...

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Main Authors:	Tomoya Ito, Yusuke Shintani, Laura Fields, Manabu Shiraishi, Mihai‑Nicolae Podaru, Satoshi Kainuma, Kizuku Yamashita, Kazuya Kobayashi, Mauro Perretti, Fiona Lewis-McDougall, Ken Suzuki
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22536-y

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spelling	doaj-04b291aa73f1460e9d361ec21581a4ce2021-04-18T11:14:11ZengNature Publishing GroupNature Communications2041-17232021-04-0112111210.1038/s41467-021-22536-yCell barrier function of resident peritoneal macrophages in post-operative adhesionsTomoya Ito0Yusuke Shintani1Laura Fields2Manabu Shiraishi3Mihai‑Nicolae Podaru4Satoshi Kainuma5Kizuku Yamashita6Kazuya Kobayashi7Mauro Perretti8Fiona Lewis-McDougall9Ken Suzuki10William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonPeritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80HighCD206− macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of these cells.https://doi.org/10.1038/s41467-021-22536-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tomoya Ito Yusuke Shintani Laura Fields Manabu Shiraishi Mihai‑Nicolae Podaru Satoshi Kainuma Kizuku Yamashita Kazuya Kobayashi Mauro Perretti Fiona Lewis-McDougall Ken Suzuki
spellingShingle	Tomoya Ito Yusuke Shintani Laura Fields Manabu Shiraishi Mihai‑Nicolae Podaru Satoshi Kainuma Kizuku Yamashita Kazuya Kobayashi Mauro Perretti Fiona Lewis-McDougall Ken Suzuki Cell barrier function of resident peritoneal macrophages in post-operative adhesions Nature Communications
author_facet	Tomoya Ito Yusuke Shintani Laura Fields Manabu Shiraishi Mihai‑Nicolae Podaru Satoshi Kainuma Kizuku Yamashita Kazuya Kobayashi Mauro Perretti Fiona Lewis-McDougall Ken Suzuki
author_sort	Tomoya Ito
title	Cell barrier function of resident peritoneal macrophages in post-operative adhesions
title_short	Cell barrier function of resident peritoneal macrophages in post-operative adhesions
title_full	Cell barrier function of resident peritoneal macrophages in post-operative adhesions
title_fullStr	Cell barrier function of resident peritoneal macrophages in post-operative adhesions
title_full_unstemmed	Cell barrier function of resident peritoneal macrophages in post-operative adhesions
title_sort	cell barrier function of resident peritoneal macrophages in post-operative adhesions
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	Peritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80HighCD206− macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of these cells.
url	https://doi.org/10.1038/s41467-021-22536-y
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Cell barrier function of resident peritoneal macrophages in post-operative adhesions

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