Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins

Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins

Use of chlorhexidine in clinical settings has led to concerns that repeated exposure of bacteria to sub-lethal doses of chlorhexidine might result in chlorhexidine resistance and cross resistance with other cationic antimicrobials including colistin, endogenous antimicrobial peptides (AMPs) and thei...

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Bibliographic Details
Main Authors: Marjan M. Hashemi, Brett S. Holden, Jordan Coburn, Maddison F. Taylor, Scott Weber, Brian Hilton, Aaron L. Zaugg, Colten McEwan, Richard Carson, Joshua L. Andersen, John C. Price, Shenglou Deng, Paul B. Savage
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
chlorhexidine
ceragenins
colistine
proteomic
cross-resistance
Pseudomonas aeruginosa
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00210/full

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