Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

Abstract Background The VRK1 chromatin kinase regulates the organization of locally altered chromatin induced by DNA damage. The combination of ionizing radiation with inhibitors of DNA damage responses increases the accumulation of DNA damage in cancer cells, which facilitates their antitumor effec...

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Bibliographic Details
Main Authors: Ignacio Campillo-Marcos, Pedro A. Lazo
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
VRK1
Vaccinia-related kinase 1
Olaparib
Ionizing radiation
H2AX
NBS1
Online Access:http://link.springer.com/article/10.1186/s13046-019-1204-1

Internet

http://link.springer.com/article/10.1186/s13046-019-1204-1

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