Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

Burgeoning evidence has indicated that normal autophagy is required for nuclear factor erythroid 2-related factor (Nrf2)-mediated cardiac protection whereas autophagy inhibition turns on Nrf2-mediated myocardial damage and dysfunction in a setting of pressure overload (PO). However, such a concept r...

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Bibliographic Details
Main Authors: Weiwei Wu, Qingyun Qin, Yan Ding, Huimei Zang, Dong-Sheng Li, Mitzi Nagarkatti, Prakash Nagarkatti, Wenjuan Wang, Xuejun Wang, Taixing Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
Nrf2
autophagy
ERK
cardiac dysfunction
pressure overload
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.673145/full

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