Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Abstract Background The gut microbiota plays crucial roles in the development of non-alcoholic steatohepatitis (NASH). However, the precise mechanisms by which alterations of the gut microbiota and its metabolism contributing to the pathogenesis of NASH are not yet fully elucidated. Methods Mice wer...

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Bibliographic Details
Main Authors: Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai, Hidetsugu Saito
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Gastroenterology
Subjects:
Gut microbiota
Non-alcoholic steatohepatitis
Long-chain saturated fatty acids
Fat accumulation
Fat transportation
Online Access:http://link.springer.com/article/10.1186/s12876-017-0689-3

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