Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, poly...

Full description

Bibliographic Details
Main Authors: Jalani G, Jung CW, Lee JS, Lim DW
Format: Article
Language:English
Published: Dove Medical Press 2014-05-01
Series:International Journal of Nanomedicine
Online Access:http://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692
id doaj-0498dd0771cc4a04ae70b3e0e719ffaa
record_format Article
spelling doaj-0498dd0771cc4a04ae70b3e0e719ffaa2020-11-24T22:41:42ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-05-012014Supplement 1334916692Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systemsJalani GJung CWLee JSLim DW Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineeringhttp://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692
collection DOAJ
language English
format Article
sources DOAJ
author Jalani G
Jung CW
Lee JS
Lim DW
spellingShingle Jalani G
Jung CW
Lee JS
Lim DW
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
International Journal of Nanomedicine
author_facet Jalani G
Jung CW
Lee JS
Lim DW
author_sort Jalani G
title Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_short Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_full Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_fullStr Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_full_unstemmed Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_sort fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
publisher Dove Medical Press
series International Journal of Nanomedicine
issn 1178-2013
publishDate 2014-05-01
description Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineering
url http://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692
work_keys_str_mv AT jalanig fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems
AT jungcw fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems
AT leejs fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems
AT limdw fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems
_version_ 1725701107366232064