Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, poly...
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doaj-0498dd0771cc4a04ae70b3e0e719ffaa2020-11-24T22:41:42ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-05-012014Supplement 1334916692Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systemsJalani GJung CWLee JSLim DW Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineeringhttp://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jalani G Jung CW Lee JS Lim DW |
spellingShingle |
Jalani G Jung CW Lee JS Lim DW Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems International Journal of Nanomedicine |
author_facet |
Jalani G Jung CW Lee JS Lim DW |
author_sort |
Jalani G |
title |
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
title_short |
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
title_full |
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
title_fullStr |
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
title_full_unstemmed |
Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
title_sort |
fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2014-05-01 |
description |
Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineering |
url |
http://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692 |
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