Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to und...

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Bibliographic Details
Main Authors: Noboru Suzuki, Tomoko Suzuki, Yuji Ueda, Takao Kono, Erika Takada, Naruyoshi Fujiwara, Nagisa Arimitsu, Kenji Takai, Jun Shimizu
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:International Journal of Molecular Sciences
Subjects:
neural stem/progenitor cells
chemokines
cell migration
chemokine receptor
Online Access:http://www.mdpi.com/1422-0067/13/3/2636/
Description
Summary:Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.
ISSN:1422-0067

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