Positive Culture Prior to Transperineal Prostate Biopsy Was Not Associated with Post-Biopsy Febrile Urinary Tract Infection Development

• Main Authors: Tohi Y, Fujiwara K, Harada S, Matsuda I, Ito A, Yamasaki M, Miyauchi Y, Matsuoka Y, Kato T, Taoka R, Tsunemori H, Ueda N, Sugimoto M
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-09-01
• Series: Research and Reports in Urology
• Subjects: rinary tract infection; prostate biopsy; transperineal; urine culture
• Online Access: https://www.dovepress.com/positive-culture-prior-to-transperineal-prostate-biopsy-was-not-associ-peer-reviewed-fulltext-article-RRU

Yoichiro Tohi, Kengo Fujiwara, Satoshi Harada, Iori Matsuda, Ayako Ito, Mari Yamasaki, Yasuyuki Miyauchi, Yuki Matsuoka, Takuma Kato, Rikiya Taoka, Hiroyuki Tsunemori, Nobufumi Ueda, Mikio Sugimoto Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, JapanCorrespondence: Yoichiro TohiDepartment of Urology, Faculty of Medicine, Kagawa University, Kagawa, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, JapanTel [phone]Fax [phone]Email [e-mail]: To investigate the association between urine culture before transperineal prostate biopsy and post-biopsy febrile urinary tract infection (fUTI).Patients and Methods: We retrospectively reviewed 307 patients who underwent urine culture before transperineal prostate biopsy between April 2017 and September 2020. Patients with indwelling urinary catheters (n=7) were excluded. Urine culture was performed 1– 3 days before the biopsy, and all patients received prophylactic cefazolin regardless of culture results. A urine culture was defined as positive if cell density was more than 1× 105 colony-forming units per mL. Baseline characteristics and the incidence of post-biopsy fUTI were compared between patients showing positive pre-biopsy culture results and those showing negative findings.Results: Out of 300, seven patients (2.3%) had positive urine culture results before the biopsy. Age (p=0.077); prostate-specific antigen at diagnosis (p=0.267); prostate volume (p=0.78); number of biopsy cores (p=0.277); percentage of patients testing positive for cancer on biopsy (p=0.71); and percentages of patients with a history of biopsy (p> 0.999), diabetes mellitus (p=0.604), and immunosuppressive medication use (p> 0.999) were similar between the two groups. No patient in the positive urine culture group had post-biopsy fUTI. However, 1.7% (five patients) of the negative urine culture group had the disease (p> 0.999) (four patients with prostatitis and one with pyelonephritis). Among them, two patients were diagnosed by urine culture at the time of post-biopsy fUTI.Conclusion: In asymptomatic patients, positive pre-biopsy cultures were not associated with the development of post-biopsy fUTI.Keywords: urinary tract infection, prostate biopsy, transperineal, urine culture