PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia

PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia

Modification of N-methyl-d-aspartate receptor (NMDAR)-mediated excitotoxicity appears to be a potential target in the treatment of ischemic stroke. Postsynaptic density protein-93 (PSD-93) specifically binds the C-terminal tails of the NMDAR, which is critical to couple NMDAR activity to specific in...

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Bibliographic Details
Main Authors: Meijuan Zhang, Qingjie Li, Ling Chen, Jie Li, Xin Zhang, Xiang Chen, Qingxiu Zhang, Yuan Shao, Yun Xu
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
NMDAR
PSD-93
Fyn
Tyrosine phosphorylation
Ischemic stroke
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000990

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