Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease

• Main Authors: Federico Biscetti, Elisabetta Nardella, Nicola Bonadia, Flavia Angelini, Dario Pitocco, Angelo Santoliquido, Marco Filipponi, Raffaele Landolfi, Andrea Flex
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: Cardiovascular Diabetology
• Subjects: Omentin-1; Peripheral artery disease (PAD); Type 2 diabetes; Atherosclerosis
• Online Access: http://link.springer.com/article/10.1186/s12933-019-0880-7

Abstract Background Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients. Methods In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine’s stage II, III, or IV. Results We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis. Conclusions Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.