Status and Advances of RGD Molecular Imaging in Lung Cancer

• Main Authors: Ning YUE, Shuanghu YUAN, Guoren YANG
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2014-12-01
• Series: Chinese Journal of Lung Cancer
• Subjects: RGD; Integrin; Lung neoplasms; Molecular imaging; Angiogenesis
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2014.12.06

Lung cancer has been one of the most common and the highest mortality rates malignant tumors at home and abroad. Sustained angiogenesis was not only the characteristic of malignant tumors, but also the foundation of tumor proliferation, invasion, recurrence and metastasis, it was also one of the hot spots of treatments in lung cancer biology currently. Integrins played an important part in tumor angiogenesis. Arg-Gly-Asp (RGD) peptides could combine with integrins specifically, and the application of radionuclide-labeled RGD molecular probes enabled imaging of tumor blood vessels to reflect its changes. The lung cancer imaging of RGD peptides at home and abroad in recent years was reviewed in this article.