Human Wharton's jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

Human Wharton's jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

Abstract Background Fulminant hepatitis is a severe life-threatening clinical condition with rapid progressive loss of liver function. It is characterized by massive activation and infiltration of immune cells into the liver and disturbance of inflammatory cytokine production. Mesenchymal stem cells...

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Bibliographic Details
Main Authors: Lijie Pan, Chang Liu, Qiuli Liu, Yanli Li, Cong Du, Xinmei Kang, Shuai Dong, Zhuowei Zhou, Huaxin Chen, Xiaoqi Liang, Jiajie Chu, Yan Xu, Qi Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Stem Cell Research & Therapy
Subjects:
Fulminant hepatitis
Human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs)
Immunomodulation
Concanavalin A (Con A)
NF-κB
Glycolysis
Online Access:https://doi.org/10.1186/s13287-021-02560-x

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