Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neuroblastoma

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neuroblastoma

The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mechanisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivatio...

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Bibliographic Details
Main Authors: Marialaura ePetroni, Veronica eVeschi, Alberto eGulino, Giuseppe eGiannini
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Oncology
Subjects:
Neuroblastoma
p53
MDM2
HIPK2
MYCN
HMGA1a
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00141/full

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