The rise and rise of mitochondrial DNA mutations

How mitochondrial DNA mutations clonally expand in an individual cell is a question that has perplexed mitochondrial biologists for decades. A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic diseases, neurodegenerative diseases, neuromuscu...

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Bibliographic Details
Main Authors: Conor Lawless, Laura Greaves, Amy K. Reeve, Doug M. Turnbull, Amy E. Vincent
Format: Article
Language:English
Published: The Royal Society 2020-05-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200061