Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow fibrosis is pa...

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Main Authors: Iman Abou Dalle, Samer Nassif, Ali Bazarbachi
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387616300553
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spelling doaj-0450111c195048d4834f64b91169c8a12020-11-25T00:38:19ZengElsevierHematology/Oncology and Stem Cell Therapy1658-38762018-06-0111299104Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literatureIman Abou Dalle0Samer Nassif1Ali Bazarbachi2Department of Internal Medicine, Hematology–Oncology Division, American University of Beirut Medical Center, Beirut, LebanonDepartment of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, LebanonDepartment of Internal Medicine, Hematology–Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon; Corresponding author at: Department of Internal Medicine, American University of Beirut Medical Center, Post Office Box 113-6044, Beirut, Lebanon.Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow fibrosis is particularly common in acute megakaryoblastic leukemia, while this change is rarely seen in acute promyelocytic leukemia. Six case reports of acute promyelocytic leukemia with marrow reticulin fibrosis have been described so far in the literature. Herein, we present three cases of classical acute promyelocytic leukemia with increased marrow reticulin fibrosis encountered in our institution, summarizing their clinicopathologic features, treatment, and outcome to date. Awareness of the features of acute promyelocytic leukemia with marrow reticulin fibrosis is important as it may guide treatment options. Keywords: Acute promyelocytic leukemia, Bone marrow, Case report, Fibrosis, Reticulin, Reviewhttp://www.sciencedirect.com/science/article/pii/S1658387616300553
collection DOAJ
language English
format Article
sources DOAJ
author Iman Abou Dalle
Samer Nassif
Ali Bazarbachi
spellingShingle Iman Abou Dalle
Samer Nassif
Ali Bazarbachi
Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
Hematology/Oncology and Stem Cell Therapy
author_facet Iman Abou Dalle
Samer Nassif
Ali Bazarbachi
author_sort Iman Abou Dalle
title Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
title_short Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
title_full Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
title_fullStr Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
title_full_unstemmed Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature
title_sort acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: description of three cases and review of the literature
publisher Elsevier
series Hematology/Oncology and Stem Cell Therapy
issn 1658-3876
publishDate 2018-06-01
description Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow fibrosis is particularly common in acute megakaryoblastic leukemia, while this change is rarely seen in acute promyelocytic leukemia. Six case reports of acute promyelocytic leukemia with marrow reticulin fibrosis have been described so far in the literature. Herein, we present three cases of classical acute promyelocytic leukemia with increased marrow reticulin fibrosis encountered in our institution, summarizing their clinicopathologic features, treatment, and outcome to date. Awareness of the features of acute promyelocytic leukemia with marrow reticulin fibrosis is important as it may guide treatment options. Keywords: Acute promyelocytic leukemia, Bone marrow, Case report, Fibrosis, Reticulin, Review
url http://www.sciencedirect.com/science/article/pii/S1658387616300553
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AT samernassif acutepromyelocyticleukemiawithincreasedbonemarrowreticulinfibrosisdescriptionofthreecasesandreviewoftheliterature
AT alibazarbachi acutepromyelocyticleukemiawithincreasedbonemarrowreticulinfibrosisdescriptionofthreecasesandreviewoftheliterature
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