Cyclic Helix B Peptide Prolongs Skin Allograft Survival via Inhibition of B Cell Immune Responses in a Murine Model

Cyclic Helix B Peptide Prolongs Skin Allograft Survival via Inhibition of B Cell Immune Responses in a Murine Model

Antibody-mediated rejection (AMR) represents a major cause of allograft dysfunction and results in allograft failure in solid organ transplantation. Cyclic helix B peptide (CHBP) is a novel erythropoietin-derived peptide that ameliorated renal allograft rejection in a renal transplantation model. Ho...

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Bibliographic Details
Main Authors: Long Zheng, Xuanchuan Wang, Linkun Hu, Wenjun Gao, Weitao Zhang, Xuepeng Zhang, Chao Hu, Ruiming Rong, Cheng Yang, Dong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
cyclic helix B peptide
antibody-mediated rejection
plasma cells
germinal center B cells
Tfh cells
donor specific antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.682749/full

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