Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection

Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection

Current antibiotic treatments fail to eliminate the Clostridium difficile (C. difficile) spores and induce dysbiosis and intestinal inflammation via off-target effect, which causes refractory C. difficile infection raise an unmet need for a spore-specific antimicrobial treatment. We developed a spor...

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Bibliographic Details
Main Authors: Yi-Hsuan Chen, Tsung-Ju Li, Bo-Yang Tsai, Liang-Kuei Chen, Yi-Hsin Lai, Meng-Jia Li, Cheng-Yang Tsai, Pei-Jane Tsai, Dar-Bin Shieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
Clostridium difficile
spore
nanoparticle
target therapeutics
antibiotics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01141/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01141/full

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