Initiation of genome instability and preneoplastic processes through loss of Fhit expression.

Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile F...

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Bibliographic Details
Main Authors: Joshua C Saldivar, Satoshi Miuma, Jessica Bene, Seyed Ali Hosseini, Hidetaka Shibata, Jin Sun, Linda J Wheeler, Christopher K Mathews, Kay Huebner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3510054?pdf=render

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