Restoration of uridine 5′-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells

Restoration of uridine 5′-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells

We have demonstrated that KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) blunts monocrotaline-induced pulmonary arterial hypertension by altering Ca2+ sensitivity, K+-channel function, endothelial nitric oxide synthase activity, and RhoA/Rho kinase (ROCK) expression. This...

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Bibliographic Details
Main Authors: Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu
Format: Article
Language:English
Published: Wiley 2016-12-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
KDR channels
KMUP-1
Patch-clamp electrophysiology
Pulmonary artery smooth muscle cells
RhoA/ROCK signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X16302716

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