Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

Glycosylphosphatidylinositol (GPI) anchors attach nearly 150 proteins to the cell membrane. Patients with pathogenic variants in GPI biosynthesis genes develop diverse phenotypes including seizures, dysmorphic facial features and cleft palate through an unknown mechanism. We identified a novel mouse...

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Bibliographic Details
Main Authors: Marshall Lukacs, Tia Roberts, Praneet Chatuverdi, Rolf W Stottmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
glycosylphosphatidylinositol
craniofacial
neural crest
congenital disorders of glycosylation
Folic/folinic acid
development
Online Access:https://elifesciences.org/articles/45248

Internet

https://elifesciences.org/articles/45248

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