Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with membrane compartmentalization used to isolate the t...

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Main Authors:	Jonathan Latham, Jean-Marc Henry, Humera H. Sharif, Binuraj R. K. Menon, Sarah A. Shepherd, Michael F. Greaney, Jason Micklefield
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11873

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spelling	doaj-0433d1f6927342b4876e95b9f595c6da2021-05-11T11:05:24ZengNature Publishing GroupNature Communications2041-17232016-06-01711810.1038/ncomms11873Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activationJonathan Latham0Jean-Marc Henry1Humera H. Sharif2Binuraj R. K. Menon3Sarah A. Shepherd4Michael F. Greaney5Jason Micklefield6School of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterSchool of Chemistry, The University of ManchesterBiocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with membrane compartmentalization used to isolate the two chemistries.https://doi.org/10.1038/ncomms11873
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jonathan Latham Jean-Marc Henry Humera H. Sharif Binuraj R. K. Menon Sarah A. Shepherd Michael F. Greaney Jason Micklefield
spellingShingle	Jonathan Latham Jean-Marc Henry Humera H. Sharif Binuraj R. K. Menon Sarah A. Shepherd Michael F. Greaney Jason Micklefield Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation Nature Communications
author_facet	Jonathan Latham Jean-Marc Henry Humera H. Sharif Binuraj R. K. Menon Sarah A. Shepherd Michael F. Greaney Jason Micklefield
author_sort	Jonathan Latham
title	Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
title_short	Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
title_full	Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
title_fullStr	Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
title_full_unstemmed	Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
title_sort	integrated catalysis opens new arylation pathways via regiodivergent enzymatic c–h activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-06-01
description	Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with membrane compartmentalization used to isolate the two chemistries.
url	https://doi.org/10.1038/ncomms11873
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Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

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