B7-H3-Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns

B7-H3-Induced Signaling in Lung Adenocarcinoma Cell Lines with Divergent Epidermal Growth Factor Receptor Mutation Patterns

The cosignal molecule B7-H3 is gaining attention due to its abnormal expression and abundant signal transduction in many types of malignancies. B7-H3-induced signaling includes at least three cascades: PI3K/AKT, JAK2/STAT3, and Raf/MEK/ERK1/2, which are also involved in epidermal growth factor recep...

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Bibliographic Details
Main Authors:	Meng Ding, Haixiu Liao, Nannan Zhou, Ying Yang, Shihe Guan, Liwen Chen
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2020/8824805

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