Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-α

Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-α

Membrane type-1 matrix metalloproteinase (MT1-MMP) has been implicated in tumor invasion, as well as trafficking of normal hematopoietic cells, and acts as a physiologic activator of proMMP-2. In this study we examined MT1-MMP expression in primary acute myeloid leukemia (AML) cells. Because tumor n...

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Bibliographic Details
Main Authors: Anna Janowska-Wieczorek, Loree M. Larratt, Amir Surmawala, Imran Mirza, A. Robert Turner, Leah A. Marquez-Curtis, Neeta Shirvaikar
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Cancers
Subjects:
acute myeloid leukemia
membrane type 1-matrix metalloproteinase
matrix metalloproteinase-2
tumor necrosis factor-α
Online Access:http://www.mdpi.com/2072-6694/4/3/743

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