Glucocorticoid Priming of Nonviral Gene Delivery to hMSCs Increases Transfection by Reducing Induced Stresses

Glucocorticoid Priming of Nonviral Gene Delivery to hMSCs Increases Transfection by Reducing Induced Stresses

Human mesenchymal stem cells (hMSCs) are under study for cell and gene therapeutics because of their immunomodulatory and regenerative properties. Safe and efficient gene delivery could increase hMSC clinical potential by enabling expression of transgenes for control over factor production, behavior...

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Bibliographic Details
Main Authors: Andrew Hamann, Tyler Kozisek, Kelly Broad, Angela K. Pannier
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
transfection
nonviral gene delivery
mesenchymal stem cell
priming
glucocorticoid
dexamethasone
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301637

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