Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.

Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.

Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n = 190) and 23% breast (n = 80) tumors...

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Bibliographic Details
Main Authors: Mathewos Tessema, Christin M Yingling, Marcie J Grimes, Cynthia L Thomas, Yushi Liu, Shuguang Leng, Nancy Joste, Steven A Belinsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3319602?pdf=render

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