A transcribed enhancer dictates mesendoderm specification in pluripotency

A transcribed enhancer dictates mesendoderm specification in pluripotency

Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling...

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Main Authors: Michael Alexanian, Daniel Maric, Stephen P. Jenkinson, Marco Mina, Clayton E. Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L. Leib, Nathan J. Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01804-w
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spelling doaj-0401f32188554c209d1d26fb94e3d2e82021-05-11T07:26:05ZengNature Publishing GroupNature Communications2041-17232017-11-018111910.1038/s41467-017-01804-wA transcribed enhancer dictates mesendoderm specification in pluripotencyMichael Alexanian0Daniel Maric1Stephen P. Jenkinson2Marco Mina3Clayton E. Friedman4Ching-Chia Ting5Rudi Micheletti6Isabelle Plaisance7Mohamed Nemir8Damien Maison9Jasmin Kernen10Iole Pezzuto11Dominic Villeneuve12Frédéric Burdet13Mark Ibberson14Stephen L. Leib15Nathan J. Palpant16Nouria Hernandez17Samir Ounzain18Thierry Pedrazzini19Experimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolNeuroinfectiology Laboratory, Institute for Infectious Diseases, University of BernDepartment of Computational Biology, University of LausanneThe Institute for Molecular Bioscience, University of QueenslandExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolNeuroinfectiology Laboratory, Institute for Infectious Diseases, University of BernExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolCenter for Integrative Genomics, Faculty of Biology and Medicine, University of LausanneSwiss Institute of BioinformaticsSwiss Institute of BioinformaticsNeuroinfectiology Laboratory, Institute for Infectious Diseases, University of BernThe Institute for Molecular Bioscience, University of QueenslandCenter for Integrative Genomics, Faculty of Biology and Medicine, University of LausanneExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolExperimental Cardiology Unit, Department of Cardiovascular Medicine, University of Lausanne Medical SchoolLong noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.https://doi.org/10.1038/s41467-017-01804-w
collection DOAJ
language English
format Article
sources DOAJ
author Michael Alexanian
Daniel Maric
Stephen P. Jenkinson
Marco Mina
Clayton E. Friedman
Ching-Chia Ting
Rudi Micheletti
Isabelle Plaisance
Mohamed Nemir
Damien Maison
Jasmin Kernen
Iole Pezzuto
Dominic Villeneuve
Frédéric Burdet
Mark Ibberson
Stephen L. Leib
Nathan J. Palpant
Nouria Hernandez
Samir Ounzain
Thierry Pedrazzini
spellingShingle Michael Alexanian
Daniel Maric
Stephen P. Jenkinson
Marco Mina
Clayton E. Friedman
Ching-Chia Ting
Rudi Micheletti
Isabelle Plaisance
Mohamed Nemir
Damien Maison
Jasmin Kernen
Iole Pezzuto
Dominic Villeneuve
Frédéric Burdet
Mark Ibberson
Stephen L. Leib
Nathan J. Palpant
Nouria Hernandez
Samir Ounzain
Thierry Pedrazzini
A transcribed enhancer dictates mesendoderm specification in pluripotency
Nature Communications
author_facet Michael Alexanian
Daniel Maric
Stephen P. Jenkinson
Marco Mina
Clayton E. Friedman
Ching-Chia Ting
Rudi Micheletti
Isabelle Plaisance
Mohamed Nemir
Damien Maison
Jasmin Kernen
Iole Pezzuto
Dominic Villeneuve
Frédéric Burdet
Mark Ibberson
Stephen L. Leib
Nathan J. Palpant
Nouria Hernandez
Samir Ounzain
Thierry Pedrazzini
author_sort Michael Alexanian
title A transcribed enhancer dictates mesendoderm specification in pluripotency
title_short A transcribed enhancer dictates mesendoderm specification in pluripotency
title_full A transcribed enhancer dictates mesendoderm specification in pluripotency
title_fullStr A transcribed enhancer dictates mesendoderm specification in pluripotency
title_full_unstemmed A transcribed enhancer dictates mesendoderm specification in pluripotency
title_sort transcribed enhancer dictates mesendoderm specification in pluripotency
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.
url https://doi.org/10.1038/s41467-017-01804-w
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